CJC-1295 with DAC

Description

Mechanism of Action：

• CJC-1295 is a synthetic peptide that mimics the function of natural GHRH, stimulating the anterior pituitary gland to release more endogenous growth hormone. The addition of a  drug affinity complex (DAC) significantly alters its mechanism of action:
• Albumin Binding: The DAC molecular structure allows CJC-1295 to bind to serum albumin (a common plasma protein) in the blood.
• Extended Half-Life: This binding protects the peptide from rapid enzymatic degradation, allowing it to remain in the bloodstream for a longer period. The estimated half-life of CJC-1295 with DAC is approximately 6 to 8 days, while the half-life of the version without DAC (also known as Mod GRF 1-29) is only about 30 minutes to 2 hours.
• Sustained Release: This long-acting mechanism allows for a sustained increase in growth hormone levels, rather than the short-lived, pulsatile release seen in natural GHRH or DAC-free versions.
• Key Advantages: The unique advantages of CJC-1295 with DAC lie in the convenience and effectiveness brought about by its pharmacokinetic properties:
  Reduced Injection Frequency: Due to its long duration of action, it typically requires only 1 or 2 injections per week to maintain its effect, making it very convenient.
• Sustained Increase in GH and IGF-1: A single injection can increase plasma GH levels by 2 to 10 times and plasma IGF-1 levels by 0.5 to 3 times over 6 days or longer, lasting for 9 to 11 days.
• Potential Benefits: This sustained increase in GH and IGF-1 levels may contribute to：
  Increase muscle mass
  Promote fat metabolism and reduce body fat
  Improve recovery time and sleep quality
  Enhance cognitive function
  Improve skin elasticity and bone density